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Traction force microscopy for understanding cellular mechanotransduction
Sung Sik Hur1,2, Ji Hoon Jeong1,2, Jeong Ban3, Jae Hong Park3, Jeong Kyo Yoon1,2, Yongsung Hwang1,2,*
1Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Republic of Korea,
2Department of Integrated Biomedical Science, Soonchunhyang University, Asan-si, Chungcheongnam-do 31538, Republic of Korea,
3Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Republic of Korea
Abstract
Under physiological and pathological conditions, mechanical forces generated from cells themselves or transmitted from extracellular matrix (ECM) through focal adhesions (FAs) and adherens junctions (AJs) are known to play a significant role in regulating various cell behaviors. Substantial progresses have been made in the field of mechanobiology towards novel methods to understand how cells are able to sense and adapt to these mechanical forces over the years. To address these issues, this review will discuss recent advancements of traction force microscopy (TFM), intracellular force microscopy (IFM), and monolayer stress microscopy (MSM) to measure multiple aspects of cellular forces exerted by cells at cell-ECM and cell-cell junctional intracellular interfaces.
Abstract, Accepted Manuscript [Submitted on December 18, 2019, Accepted on January 20, 2020]
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