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Functional Roles of Protein Phosphatase 4 in Multiple Aspects of Cellular Physiology: A Friend and A Foe
Jaehong Park 1 (Graduate student), Dong-Hyun Lee 2,3,* (Prefessor)
1School of Biological Sciences and Biotechnology Graduate School, Chonnam National University, Gwangju 61186, Korea,
2Department of Biological Sciences, College of Natural Sciences, Chonnam National University, Gwangju 61186, Korea,
3Research Center of Ecomimetics, Chonnam National University, Gwangju 61186, Korea
Abstract
Protein phosphatase 4 (PP4), one of serine/threonine phosphatases, is involved in many critical cellular pathways, including DNA damage response (DNA repair, cell cycle regulation, and apoptosis), tumorigenesis, cell migration, immune response, stem cell development, glucose metabolism, and diabetes. PP4 has been steadily studied over the past decade about wide spectrum of physiological activities in cells. Given the many vital functions in cells, PP4 has great potential to develop into the finding of key working mechanisms and effective treatments for related diseases such as cancer and diabetes. In this review, we provide an overview of the cellular and molecular mechanisms by which PP4 impacts and also discuss the functional significance of it in cell health.
Abstract, Accepted Manuscript [Submitted on January 30, 2020, Accepted on March 19, 2020]
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