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COVID-19: An update on diagnostic and therapeutic approaches
Mahalaxmi Iyer1 (Research Scholar), Kaavya Jayaramayya1 (Research Scholar), Mohana Devi Subramaniam2 (Principal Scientist), Soo Bin Lee3 (Research Scholar), Ahmed Abdal Dayem3 (Post-doctoral fellow), Ssang-Goo Cho3 (Professor), Balachandar Vellingiri4,* (Assistant Professor)
1Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641-043, India,
2Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600- 006, India,
3Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, South Korea,
4Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641-046, India
Abstract
The novel coronavirus 2019 (COVID-19), the unexpected pandemic has caused severe panic among people worldwide. The COVID-19 has created havoc, and the scientists and physicians are urged to test the efficiency and safety of drugs used to treat this disease. In such a pandemic situation, various steps have been taken by the Government to control and prevent the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic situation has forced scientists to rework strategies to combat infectious diseases through drugs, treatment, and control measures. COVID-19 treatment requires both limiting viral multiplication and neutralizing inappropriate immune reaction induced tissue damage. Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. As the global demand for diagnostics and therapeutics continue to rise, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. This review discusses the updates on specimens/samples, recent efficient diagnostics and therapeutic approaches to control the disease and repurposed drugs mainly focusing on chloroquine/hydroxychloroquine, convalescent plasma (CP). More research is required for further understanding of the influence of diagnostics and therapeutic approaches to develop vaccines and drugs for COVID-19.
Abstract, Accepted Manuscript(in press) [Submitted on April 20, 2020, Accepted on April 20, 2020]
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