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This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

 
Lysophosphatidylcholine aggravates contact hypersensitivity by promoting neutrophil infiltration and IL17 expression
Mi Hye Song1 (Graduate student), Anupriya Gupta1 (Graduate student), Hye One Kim2 (Professor), Kwonik Oh 1,3,* (Professor)
1Department of Pathology, Hallym University College of Medicine,
2Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine,
3Institute of Medical Science, Hallym University College of Medicine
Abstract
Lysophosphatidylcholine (LPC) is a bioactive lysolipid and known to contribute to the development of lung allergic diseases. However, it remains unknown whether LPC possesses proinflammatory properties in skin as well. Here, we investigated this issue by injection of LPC into the murine contact hypersensitivity (CHS) model induced by 2,4-dinitrofluorobenzene (DNFB). LPC increased the expression of IL17, recruited more neutrophils and eventually aggravated the CHS in the skins. Moreover, the effects of LPC diminished after neutralizing IL17 or depleting neutrophils. Mechanistically, LPC upregulated not only IL17 but also CXCL1 and CXCL2 in a G2A dependent manner. Taken together, our study demonstrated that the upregulation of LPC could contribute to allergic skin inflammation by enhancing IL17 expression and neutrophil recruitment via G2A receptor.
Abstract, Accepted Manuscript(in press) [Submitted on September 8, 2020, Accepted on November 4, 2020]
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