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This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

 
The Soma-Germline Communication: Implications for Somatic and Reproductive Aging
Matthew Gaddy 1 (Graduate Student), Swana Kuang1 (Undergraduate Student), Mohammad Alfhili 2 (Assistant Professor), Myon Hee Lee 1,* (Associate Professor)
1Internal Medicine, Brody School of Medicine at East Carolina University,
2Clinical Laboratory Sciences, King Saud University
Abstract
Aging is characterized by a functional decline in most physiological processes, including alterations in cellular metabolism and defense mechanisms. Increasing evidence suggests that caloric restriction extends longevity and retards age-related diseases at least in part by reducing metabolic rate and oxidative stress in a variety of species, including yeast, worms, flies, and mice. Moreover, recent studies in invertebrates – worms and flies, highlight the intricate interrelation between reproductive longevity and somatic aging (known as disposable soma theory of aging), which appears to be conserved in vertebrates. This review is specifically focused on how the reproductive system modulates somatic aging and vice versa in genetic model systems. Since many signaling pathways governing the aging process are evolutionarily conserved, similar mechanisms may be involved in controlling soma and reproductive aging in vertebrates.
Abstract, Accepted Manuscript(in press) [Submitted on September 14, 2020, Accepted on December 13, 2020]
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