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The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration
Hyun Woo Park1 (Graduate student), Min Seok Song1 (Graduate student), Hun Ju Sim1 (Graduate student), Pan Dong Ryu1 (Professor), So Yeong Lee1,* (Professor)
1Laboratory of Veterinary Pharmacology, Seoul National University
Abstract
Voltage-gated potassium (Kv) channels are involved in many important cellular functions, and they play pivotal roles in cancer progression. The expression level of Kv2.1 was higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and in comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti-oxidants, such as N-acetylcysteine or ascorbic acid, implying that the highly expressed Kv2.1 could detect a reactive oxygen species (ROS) in malignant prostate cancer cells. In addition, the blockade of Kv2.1 with stromatoxin-1 or siRNA targeting Kv2.1 significantly inhibited the migration of malignant prostate cancer cells. Our results suggested that Kv2.1 plays an important role as a ROS sensor and that it is a promising therapeutic molecular target in metastasis of prostate cancer.
Abstract, Accepted Manuscript(in press) [Submitted on September 25, 2020, Accepted on December 8, 2020]
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