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The Role of Dendritic Cells in Tumor Microenvironments and Their Uses as Therapeutic Targets
Chae Won Kim 1 (Ph.D student), Kyun-Do Kim 2,# (Senior Researcher), Heung Kyu Lee 1,3,*,# (Associate Professor)
1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology,
2Center for Convergent Research of Emerging Virus Infection, Korea Research Institute of Chemical Technology,
3BioMedical Research Center, KAIST
Dendritic cells (DC), which consist of several different subsets, specialize in antigen presentation and are critical for mediating the innate and adaptive immune responses. DC subsets can be classified into conventional, plasmacytoid, and monocyte-derived DC in the tumor microenvironment, and each subset plays a different role. Because of the role of intratumoral DCs in initiating antitumor immune responses with tumor-derived antigen presentation to T cells, DCs have been targeted in the treatment of cancer. By regulating the functionality of DCs, several DC-based immunotherapies have been developed, including administration of tumor-derived antigens and DC vaccines. In addition, DCs participate in the mechanisms of classical cancer therapies, such as radiation therapy and chemotherapy. Thus, regulating DCs is also important in improving current cancer therapies. Here, we will discuss the role of each DC subset in antitumor immune responses, and the current status of DC-related cancer therapies.
Abstract, Accepted Manuscript(in press) [Submitted on October 16, 2020, Accepted on December 3, 2020]
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