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Common plasma protein marker LCAT in aggressive human breast cancer and canine mammary tumor.
Hyoung-Min Park 1,2 (Graduate student), HuiSu Kim 1,2 (Graduate student), Dong Wook Kim 1,2 (Dr.), Jong-Hyuk Yoon3 (Dr.), Byung-Gyu Kim4 (Dr.), Cho Je Yeol 1,2,* (Proffessor)
1Department of Biochemistry, BK21 Plus and Research Institute for Veterinary Science, School of Veterinary Medicine, Seoul National University, Seoul, Korea.,
2The Canine Cancer Research Center, Seoul National University, Korea.,
3Neurodegenerative Disease Research Group, Korea Brain Research Institute, Daegu 41062, Korea.,
4Center for Genomic Integrity, Institute for Basic Science, UNIST, Ulsan 44919, Korea.
Abstract
Breast cancer is one of the most frequently diagnosed cancers. While biomarkers are continuously discovered, specific markers representing the aggressiveness and invasiveness of breast cancer are lacking compared to classification markers. In this study, samples from canine mammary tumors were used in a comparative approach. An extensive 36 fractions of both canine normal and mammary tumor plasma was subjected to high-performance quantitative proteomics analysis. Among the identified proteins, LCAT was discovered to be selectively expressed in mixed tumor samples, which represents an aggressive developed stage of cancer, possibly highly metastatic. With further MRM and Western blot validation, we discovered that the LCAT protein is an indicator of aggressive mammary tumor. Interestingly, we also found that LCAT is overexpressed in high grade and lymph node positive breast cancer in silico data. We also demonstrated that LCAT is highly expressed in the sera of advanced stage human breast cancers within the same classification. In conclusion, we identified a possible common plasma protein biomarker, LCAT, that is highly expressed in aggressive human breast cancer and canine mammary tumor.
Abstract, Accepted Manuscript(in press) [Submitted on October 31, 2020, Accepted on November 24, 2020]
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