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Current understanding of cancer-intrinsic PD-L1: regulation of expression and its protumoral activity
Pedram Yadollahi1,2 (Graduate student), You-Kyoung Jeon1,2 (Post-doc), Wooi Loon Ng1,2 (Post-doc), Inhak Choi1,2,* (Professor)
1Innovative Therapeutic Research Institute, Inje University, Busan 47397, Korea,
2Department of Microbiology and Immunology, Inje University College of Medicine, Busan 47392, Korea
In the last decade, we have witnessed an unprecedented clinical success in cancer immunotherapies targeting the programmed cell-death ligand 1 (PD-L1) and programmed cell-death 1 (PD-1) pathway. Besides the fact that PD-L1 plays a key role in immune regulation in tumor microenvironment, recently a plethora of reports has suggested a new perspective of non-immunological functions of PD-L1 in the regulation of cancer intrinsic activities including mesenchymal transition, glucose and lipid metabolism, stemness, and autophagy. Here we review the current understanding on the regulation of expression and intrinsic protumoral activity of cancer-intrinsic PD-L1.
Abstract, Accepted Manuscript [Submitted on November 4, 2020, Accepted on November 30, 2020]
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