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A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development
Boksik Cha1 (Senior Researcher), Sungjin Moon 1 (Assistant professor), Wantea Kim 1,* (Assistant professor)
1Daegu Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea,
2Department of Biological Science, Kangwon National University, Chuncheon 24341, Republic of Korea,
3Department of Biochemistry, Chungnam National University, Daejeon 34134, Republic of Korea.
Abstract
The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development.
Abstract, Accepted Manuscript(in press) [Submitted on February 9, 2021, Accepted on March 3, 2021]
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