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Adipogenic function of tetranectin mediated by enhancing mitotic clonal expansion via ERK signaling
Seulgi Go1,# (Graduate student), Jihyun Park1,# (Post-doc), Hamdy Kashtoh1,# (Post-doc), Safikur Rahman2 (Professor), Juno Jin1 (Professor), Inho Choi1 (Professor), Jihoe Kim1,* (Professor)
1Medical Biotechnology and Research Institute of Cell Culture, Yeungnam University,
2Biochemistry, Jan Nayak Chaudhary Devilal Dental College
Tetranectin (TN), an adipogenic serum protein, enhances adipocyte differentiation, however, its functional mechanism has yet to be elucidated. In the present study, we investigated the adipogenic function of TN by using medium containing TN-depleted fetal bovine serum (TN-del-FBS) and recombinant mouse TN (mTN). The adipocyte differentiation of 3T3-L1 cells was significantly enhanced by mTN supplementation essentially at differentiation induction, which indicated a potential role of the protein in the early differentiation phase. The adipogenic effect of mTN was more significant with insulin in the differentiation induction cocktail, implicating their close functional relationship. mTN enhanced not only the proliferation of growing cells, but also mitotic clonal expansion (MCE) that is a prerequisite for adipocyte differentiation in the early phase. Consistently, mTN increased the phosphorylation of ERK in the early phase of adipocyte differentiation. Results of this study demonstrate that the adipogenic function of mTN is mediated by enhancing MCE via ERK signaling.
Abstract, Accepted Manuscript(in press) [Submitted on February 16, 2021, Accepted on March 6, 2021]
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