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Investigation of the effect of Staufen1 overexpression on the HIV-1 virus production
Seong-Won Park1 (Graduate student), Kyung-Lee Yu1 (Postdoctoral researcher), Jun-Hyun Bae1 (Graduate student), Ga-Na Kim1 (Graduate student), Hae-In kim1 (Graduate student), Ji-Chang You1,* (Professor)
1National Research Laboratory of Molecular Virology, Department of Pathology, School of Medicine, The Catholic University of Korea
Abstract
In this study, we investigated how Staufen1 influences the HIV-1 production. The overexpression of Staufen1 increased virus production without any negative affect on the viral infectivity. This increase was not caused by transcriptional activation; but by influencing post-transcriptional steps. Using multiple Gag protein derivatives, we confirmed that the zinc-finger domains of the HIV-1 nucleocapsid (NC) are important for its interaction with Staufen1. We also found that Staufen1 colocalized in stress granules with the mature form of the HIV-1 NC protein.
Abstract, Accepted Manuscript(in press) [Submitted on June 3, 2021, Accepted on July 7, 2021]
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