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Exercise induced beige adipogenesis in iWAT of Cidea reporter mice
Jin Kyung Kim1,2 (Graduate student), Hye Sun Go2 (Research worker), Sol Pin Kim2 (Research worker), Il Yong Kim1,2 (Research worker), Yun Hee Lee 2,3 (Professor), Seung Hyun Oh 2,4 (Professor), Ho Lee2,5 (Professor), Je Kyung Seong 1,2,* (Professor)
1Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, BK21 Plus Program for Advanced Veterinary Science, Research Institute for Veterinary Science Seoul National University, Republic of Korea,
2Korea Mouse Phenotyping Center (KMPC), Seoul, Republic of Korea,
3College of Pharmacy, Seoul National University, Republic of Korea,
4College of Pharmacy, Gachon University, Republic of Korea,
5National Cancer Center, Republic of Korea
Abstract
Obesity is caused by an imbalance between energy intake and energy expenditure. Exercise is attracting attention as one of the ways for the treatment of obesity. It can induce ‘beige adipogenesis’ in white adipose tissue, increasing total energy expenditure via energy dissipation in the form of heat. Also, beige adipogenesis can be induced by treatment with a beta-adrenergic receptor agonist. We developed a Cidea-dual reporter mouse (Cidea-P2A-Luc2-T2A-tdTomato, Luciferase/tdTomato) model to trace and measure beige adipogenesis in vivo. As a result, both exercise and injection of beta-adrenergic receptor agonist induced beige adipogenesis. It was able to detect through fluorescence and luminescence. We confirmed that exercise and beta-adrenergic receptor agonist can induce beige adipogenesis in Cidea-dual reporter mouse. This reporter mouse will be widely used for detecting beige adipogenesis in vivo.
Abstract, Accepted Manuscript(in press) [Submitted on September 16, 2021, Accepted on December 10, 2021]
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