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Endoplasmin regulates differentiation of tonsil-derived mesenchymal stem cells into chondrocytes through ERK signaling.
Hye Ryeong Kim 1,# (Graduate student), Hyeongrok Choi1,# (Graduate student), Soon Yong Park2 (Doctor), Young-Chul Song3 (Graduate student), Jae-Ho Kim3 (Professor), Sangin Shim4 (Professor), Woojin Jun5 (Professor), Jin Han6 (Professor), Kyung-Jin Kim7 (Professor), Seung-Wook Chi8 (Doctor), Sun-Hee Leem9 (Professor), Jin Woong Chung 1,* (Professor)
1Biological Science, Dong-A University,
2Research Center, Dongnam Institute of Radiological & Medical Sciences,
3Physiology, Pusan National University School of Medicine,
4Agronomy, Gyeongsang National University,
5Food and Nutrition, Chonnam National University,
6Life Sciences, College of Natural Sciences, Kyungpook National University,
7Physiology, College of Medicine, Inje University,
8Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology,
9Health Sciences, Dong-A University
Abstract
It has been well known that some species of lizard have the exceptional ability, that is ‘caudal autotomy’, as the anti-predation mechanism. After the amputation was occurred, they regenerate their new tail in a few days. The new tail section is generally shorter than the original and is composed of cartilage rather than vertebrae bone, and the skin of the regenerated tail distinctly differs from its previous appearance. We performed a proteomics analysis in extracts-derived from regenerating lizard tail tissue after amputation and found the ENPL (Endoplasmin, GRP94) as the main factor among the proteins of which up-regulated expression during regeneration. In fact, ENPL has been known to affect cell survival or proliferation. Thus, we performed farther experiments to verify that ENPL could induce chondrogenesis of mesenchymal stem cells. Mesenchymal stem cells (MSCs) are capable of differentiating into some specific cells and have self-renewal ability. Although MSCs can obtained from various tissue, the MSCs derived from tonsil tissues (Tonsil-derived Mesenchymal Stem Cells, T-MSCs) have several advantages including superior proliferation rate and differentiation capabilities, compared with MSCs derived from other tissues. In this study, we found ENPL is involved in chondrogenic differentiation of T-MSCs through suppression of ERK phosphorylation.
Abstract, Accepted Manuscript(in press) [Submitted on December 3, 2021, Accepted on January 6, 2022]
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