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This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

Regenerative medicine based on multiplexed targeting of microRNAs in stem cell-derived extracellular vesicles
Byeong-Wook Song1,2 (Professor), Sekyung Oh2 (Professor), Woochul Chang3,* (Professor)
1Institute for Bio-Medical Convergence, Catholic Kwandong University International St. Mary’s Hospital, Incheon 22711, Republic of Korea,
2Department of Medical Science, College of Medicine, Catholic Kwandong University, Incheon 22711, Korea,
3Department of Biology Education, College of Education, Pusan National University, Busan 46241, Republic of Korea
Methods used to restore damaged cells or tissue function via regeneration, repair or replacement in regenerative medicine ultimately use stem cells or their derivatives to induce response to disease and dysfunction. Stem cell-derived extracellular vesicles (EVs) are recognized as an attractive source of enriched exogenous microRNAs (miRNAs) by targeting pathological cells and overcome the obstacles faced by current cell therapy agents. However, there are some limitations that need to be addressed before using miRNA-enriched EVs derived from stem cells for multiplexed therapeutic targeting in many diseases. Here, we review the various strategies to induce effective and stable functional improvement of stem cell-derived EVs. In addition, we analyze the implications of several miRNA-enriched EV therapies improved by multiplexed targeting in diseases involving the circulatory system and nervous system. This systematic review may offer potential insights into the role of stem cell-derived therapeutics via multiplexed targeting mechanisms.
Abstract, Accepted Manuscript [Submitted on December 14, 2021, Accepted on January 10, 2022]
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