BMB Reports Papers in Press available online.

Search Papers In Press
This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

Emerging role of bystander T cell activation in autoimmune diseases
Chae-Hyeon Shim1 (Graduate student), Sookyung Cho1 ( Research worker), Young-Mi Shin1 ( Research worker), Je-Min Choi1,* (Professor)
1Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea
Autoimmune disease is known to be caused by unregulated self-antigen-specific T cells, causing tissue damage. Although antigen specificity is an important mechanism of the adaptive immune system, antigen non-related T cells have been found in the inflamed tissues in various conditions. Bystander T cell activation refers to the activation of T cells without antigen recognition. During an immune response to a pathogen, bystander activation of self-reactive T cells via inflammatory mediators such as cytokines can trigger autoimmune diseases. Other antigen-specific T cells can also be bystander-activated to induce innate immune response resulting in autoimmune disease pathogenesis along with self-antigen-specific T cells. In this review, we summarize previous studies investigating bystander activation of various T cell types (NKT, ャヤ T cells, MAIT cells, conventional CD4+, and CD8+ T cells) and discuss the role of innate-like T cell response in autoimmune diseases. In addition, we also review previous findings of bystander T cell function in infection and cancer. A better understanding of bystander-activated T cells versus antigen-stimulated T cells provides a novel insight to control autoimmune disease pathogenesis.
Abstract, Accepted Manuscript(in press) [Submitted on December 14, 2021, Accepted on January 10, 2022]
  Copyright © KSBMB. All rights reserved. / Powered by INFOrang Co., Ltd