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This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

 
ZNF204P is a stemness-associated oncogenic long non-coding RNA in hepatocellular carcinoma
Ji-Hyun Hwang1 (Graduate student), Jungwoo Lee1 (Graduate student), Won-Young Choi1 (Graduate student), Min-Jung Kim1 (Graduate student), Jiyeon Lee2 (Graduate student), Khanh Hoang Bao Chu3 (Graduate student), Lark Kyun Kim2,* (Professor), Young-Joon Kim1,3 (Professor)
1Interdisciplinary Program of Integrated OMICS for Biomedical Science, Yonsei University,
2Severance Biomedical Science Institute, Yonsei University College of Medicine,
3Department of Biochemistry, Yonsei University
Abstract
Hepatocellular carcinoma is a major health burden, and much research has been devoted to investigating its causes and therapies. Though various treatments are available, difficulties in early diagnosis and drug resistance to chemotherapy-based treatments render several ineffective. Cancer stem cell model has been used to explain formation of heterogeneous cell population within tumor mass, which is one of the underlying causes of high recurrence rate and acquired chemoresistance, highlighting the importance of CSC identification and understanding the molecular mechanisms of CSC drivers. Extracellular CSC-markers such as CD133, CD90 and EpCAM have been used successfully in CSC isolation, but studies have indicated that increasingly complex combinations are required for accurate identification. Pseudogene-derived long non-coding RNAs are useful candidates as intracellular CSC markers - factors that regulate pluripotency and self-renewal – given their cancer-specific expression and versatile regulation across several levels.
Here, we present the use of microarray data to identify stemness-associated factors in liver cancer, and selection of sole pseudogene-derived lncRNA ZNF204P for experimental validation. ZNF204P knockdown impairs cell proliferation and migration/invasion. As the cytosolic ZNF204P shares miRNA binding sites with OCT4 and SOX2, well-known drivers of pluripotency and self-renewal, we propose that ZNF204P promotes tumorigenesis through the miRNA-145-5p/OCT4,SOX2 axis.
Abstract, Accepted Manuscript(in press) [Submitted on January 4, 2022, Accepted on February 8, 2022]
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