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2-Undecanone derived from Pseudomonas aeruginosa modulates neutrophil activity
Yu Sun Jeong1 (Graduate student), Sunghyun Huh2,3 (Graduate student), Ji Cheol Kim1 (Graduate student), Ji Ye Park1 (Graduate student), ChaeEun Lee1 (Graduate student), Min-Sik Kim1 (Professor), JaeHyung Koo 1 (Professor), Yoe-Sik Bae 1,* (Professor)
1Department of Biological Sciences, Sungkyunkwan University,
2Department of New Biology and 3New Biology Research Center (NBRC), DGIST
Abstract
Pseudomonas aeruginosa (P. aeruginosa) is a well-known Gram-negative opportunistic pathogen. Neutrophils play key roles for host defense against P. aeruginosa infection. In this study, we identified a metabolite derived from P. aeruginosa regulates neutrophil activities. Using gas chromatography-mass spectrometry, we found that 2-undecanone is markedly increased in the peritoneal fluid of P. aeruginosa-infected mice. 2-Undecanone elicited the activation of neutrophils in a Gメi-phospholipase C pathway. However, 2-undecanone strongly inhibited responses to lipopolysaccharide and bactericidal activity of neutrophils against P. aeruginosa by inducing apoptosis. Our results demonstrate that 2-undecanone from P. aeruginosa limits the innate defense activity of neutrophils, suggesting that production of inhibitory metabolites is a strategy of P. aeruginosa for escaping the host immune system.
Abstract, Accepted Manuscript(in press) [Submitted on January 10, 2022, Accepted on April 5, 2022]
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