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Mass spectrometry-based approaches to explore metabolism regulating ferroptosis
Chi Thi Ngoc Nguyen 1 (Graduate student), Seon Min Kim 1 (Graduate student), Yun Pyo Kang 1,* (Assistant Professor)
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea
Abstract
Ferroptosis is a type of programmed cell death distinct from apoptosis or necroptosis. Ferroptosis is well characterized by an iron-dependent accumulation of lipid peroxides and disruption of cellular membrane integrity. Many metabolic alterations can prevent or accelerate ferroptosis induction. Recent advances in analytical techniques of mass spectrometry have allowed high-throughput analysis of metabolites for understanding ferroptosis regulatory metabolism. In this review, we introduce mass spectrometry-based analytical methods contributing to recent discovery of various metabolic pathways regulating ferroptosis, focusing on cysteine metabolism, antioxidant metabolism, and poly-unsaturated fatty acid metabolism.
Abstract, Accepted Manuscript [Submitted on July 12, 2022, Accepted on August 8, 2022]
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