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Function of gaseous hydrogen sulfide in liver disease
Jae-Ho Lee1 (Postdoctoral fellow), Seung-Soon Im 1,* (Professor)
1Department of Physiology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea
Abstract
Over the past few years, hydrogen sulfide (H2S) has been known to exert several biological functions in mammalian. The production of H2S is mainly produced by cystathione モ-synthase (CBS), 3-mercaptopyruvate sulfur transferase (3-MST), and cystathione ャ-lyase (CSE). They are broadly induced in liver and involved in liver function by working on a variety of molecular targets. As an important regulator of liver function, H2S regulates the pathogenesis of several liver diseases, such as non-alcoholic steatohepatitis (NASH) and liver fibrosis. Targeting H2S-generating enzymes is possible to be a therapeutic target for controlling liver diseases. This review described the function of H2S in liver disease and summarized recent characterized role of H2S in several cellular process of the liver.
Abstract, Accepted Manuscript(in press) [Submitted on August 17, 2022, Accepted on September 21, 2022]
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