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The Role of Immunomodulatory Metabolites in Shaping the Inflammatory Response of Macrophages
Doyoung Park1 (Graduate student), Gyumin Lim1 (Graduate student), Sung-Jin Yoon 2 (Senior researcher), Hyon-Seung Yi 3 (Professor), Dong Wook Choi 1,* (Professor)
1Department of Biochemistry, College of Natural Sciences, Chungnam National University,
2Environmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea,
3Department of Internal Medicine and Laboratory of Endocrinology and Immune System, Chungnam National University College of Medicine, Daejeon, Korea
Abstract
Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response.
A growing number of studies have functionally coupled the macrophages’ inflammatory capacities with dynamic metabolic reprogramming which occurs during activation, albeit this has been largely limited to a classic metabolism function perspective; macrophages take advantage of the rewired metabolism as a source of energy and for biosynthetic precursors. However, a specific subset of metabolic products, namely immune-modulatory metabolites, has recently emerged as significant regulatory signals which control inflammatory responses in macrophages and the relevant extracellular milieu.
In this review, we introduce recently highlighted fuel metabolites with immunomodulatory functions, with the aim of understanding their physiological and pathological relevance in the macrophage inflammatory response.
Abstract, Accepted Manuscript [Submitted on August 25, 2022, Accepted on September 20, 2022]
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