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This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

Synergistic effect of curcumin on epigallocatechin gallate-induced anticancer action in PC3 prostate cancer cells
Dae-Woon Eom1, Ji Hwan Lee2, Young-Joo Kim2, Gwi Seo Hwang3, Su-Nam Kim2, Jin Ho Kwak4, Gab Jin Cheon5, Ki Hyun Kim6, Hyuk-Jai Jang4, Jungyeob Ham2, Ki Sung Kang3,*, Noriko Yamabe3
1Department of Pathology, University of Ulsan College of Medicine,
2Natural Product Research Center, Korea Institute of Science and Technology,
3College of Korean Medicine, Gachon University,
4Department of Surgery and 5Department of Internal Medicine, University of Ulsan College of Medicine,
6School of Pharmacy, Sungkyunkwan University
Epigallocatechin gallate (EGCG) and curcumin are well known to naturally-occurring anticancer agents. The aim of this study was to verify the combined beneficial anticancer effects of curcumin and EGCG on PC3 prostate cancer cells, which are resistant to chemotherapy drugs and apoptosis inducers. EGCG showed weaker inhibitory effect on PC3 cell proliferation than two other prostate cancer cell lines, LNCaP and DU145. Co-treatment of curcumin improved antiproliferative effect of EGCG on PC3 cells. The protein expressions of p21 were significantly increased by the co-treatment of EGCG and curcumin, whereas it was not changed by the treatment with each individual compound. Moreover, treatments of EGCG and curcumin arrested both S and G2/M phases of PC3 cells. These results suggest that the enhanced inhibitory effect of EGCG on PC3 cell proliferation by curcumin was mediated by the synergic up-regulation of p21-induced growth arrest and followed cell growth arrest.
Abstract, Accepted Manuscript(in press) [Submitted on October 17, 2014, Accepted on December 1, 2014]
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