Abstract

 

Epithelial-mesenchymal transition (EMT) was widely considered a modulating factor for anoikis and cancer metastasis. We found that, in MDA-MB-231 cells, TP53I11 (Tumor Protein P53 Inducible Protein 11) suppressed the EMT and migration in vitro, and inhibited metastasis in vivo. Our findings showed that hypoxia treatment upregulated the expression of HIF1¥á but reduced TP53I11 protein level, and TP53I11 overexpression reduced the HIF1¥á expression levels under normal culture, hypoxia treatment and in xenograft of MDA-MB-231 cells. Considering HIF1¥á is a master regulator of the hypoxic response and hypoxia is a crucial inducement triggering cancer metastasis, our study suggests that TP53I11 may suppress EMT and metastasis by reducing HIF1¥á protein level in breast cancer cells.