Abstract

 

Obesity is caused by an imbalance between energy intake and energy expenditure. Exercise is attracting attention as one of the ways for the treatment of obesity. It can induce í«beige adipogenesisí» in white adipose tissue, increasing total energy expenditure via energy dissipation in the form of heat. Also, beige adipogenesis can be induced by treatment with a beta-adrenergic receptor agonist. We developed a Cidea-dual reporter mouse (Cidea-P2A-Luc2-T2A-tdTomato, Luciferase/tdTomato) model to trace and measure beige adipogenesis in vivo. As a result, both exercise and injection of beta-adrenergic receptor agonist induced beige adipogenesis. It was able to detect through fluorescence and luminescence. We confirmed that exercise and beta-adrenergic receptor agonist can induce beige adipogenesis in Cidea-dual reporter mouse. This reporter mouse will be widely used for detecting beige adipogenesis in vivo.