| Topological implications of DNA tumor viral episomes |
Kyoung-Dong Kim  3,* (Associate Professor), Eui Tae Kim 1,2 ( Assistant Professor) |
1Department of Microbiology and Immunology, Jeju National University College of Medicine, Jeju, 63241, Republic of Korea,
2Department of Biomedicine & Drug Development, Jeju National University, Jeju, 63241, Republic of Korea,
3Department of Systems Biotechnology, Chung-Ang University, Anseong, 17546, Republic of Korea |
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Abstract
A persistent DNA tumor virus infection transforms normal cells into cancer cells by either integrating its genome into the host chromosomes or retaining it as an extrachromosomal entity called an episome. Viruses have evolved mechanisms for attaching episomes to infected host cell chromatin to efficiently segregate the viral genome during mitosis. It has been reported that viral episome can affect the gene expression of the host chromosomes through interactions between the viral episomes and the epigenetic regulatory host factors. This mini review summarizes current knowledge about tethering sites of viral episomes, such as, the Epstein–Barr virus (EBV), hepatitis B virus (HBV), and Kaposi's sarcoma-associated herpesvirus (KSHV), on host chromosomes analyzed by three-dimensional genomic tools.
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| Abstract, Accepted Manuscript(in press) [Submitted on October 6, 2022, Accepted on November 15, 2022] |
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