BMB Reports Papers in Press available online.

Search Papers In Press
This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

Investigation of the effect of SRSF9 overexpression on HIV-1 production
GaNa Kim1 (Graduate student), KyungLee Yu1 (Research worker), HaeIn Kim1 (Graduate student), JiChang You1,* (Professor)
1Department of Pathology, National Research Laboratory for Molecular Virology, College of Medicine, The Catholic University
Serine-arginine-rich splicing factors (SRSFs) are members of RNA processing proteins in the serine-arginine-rich (SR) family that could regulate the alternative splicing of the human immunodeficiency virus-1 (HIV-1). Whether SRSF9 has any effect on HIV-1 regulation requires elucidation. Here, we report for the first time the effects and mechanisms of SRSF9 on HIV-1 regulation. The overexpression of SRSF9 inhibits viral production and infectivity in both HEK293T and MT-4 cells. Deletion analysis of SRSF9 determined that the RNA regulation motif domain of SRSF9 is important for anti-HIV-1 effects. Furthermore, overexpression of SRSF9 increases multiple spliced forms of viral mRNA, such as Vpr mRNA. These data suggest that SRSF9 overexpression inhibits HIV-1 production by inducing the imbalanced HIV-1 mRNA splicing that could be exploited further for a novel HIV-1 therapeutic molecule.
Abstract, Accepted Manuscript(in press) [Submitted on October 20, 2022, Accepted on November 2, 2022]
  © KSBMB. All rights reserved. / Powered by INFOrang Co., Ltd