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Intestinal organoids as advanced modeling platforms to study the role of host-microbiome interaction in homeostasis and disease
Hyung-Sik Kim 1,2,3,* (Professor), Ji-Su Ahn1,2,3 (Graduate student), Min-Jung Kang1 (Research professor), Yoojin Seo1 (Research professor)
1Department of Oral Biochemistry, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea,
2Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea,
3Education and Research Team for Life Science on Dentistry, Pusan National University, Yangsan 50612, Republic of Korea
Abstract
After birth, animals are colonized by a diverse community of microorganisms. The digestive tract is known to contain the largest number of microbiome in the body. With emergence of the gut-brain axis, the importance of gut microbiome and its metabolites in host health has been extensively studied in recent years. The establishment of organoid culture systems has contributed to studying intestinal pathophysiology by replacing current limited models. Owing to their architectural and functional complexity similar to a real organ, co-culture of intestinal organoids with gut microbiome can provide mechanistic insights into the detrimental role of pathobiont and the homeostatic function of commensal symbiont. Here organoid-based bacterial co-culture techniques for modeling host-microbe interactions are reviewed. This review also summarizes representative studies that explore impact of enteric microorganisms on intestinal organoids to provide a better understanding of host-microbe interaction in the context of homeostasis and disease.
Abstract, Accepted Manuscript [Submitted on November 9, 2022, Accepted on November 14, 2022]
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