| Aging of hair follicle stem cells and their niches |
Sekyu Choi  1,* (Professor), Hansaem Jang 1 (Graduate student), Yemin Jo 1 (Undergraduate student), Jung Hyun Lee1 (Professor) |
1Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea,
2Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA 98109, United States,
3Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, United States,
4School of Medical Science and Engineering and 5School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea,
6Institute for Convergence Research and Education in Advanced Technology (I_CREATE), Yonsei University, Incheon 21983, Republic of Korea |
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Abstract
Hair follicles in the skin undergo cyclic rounds of regeneration, degeneration, and rest throughout life. Stem cells residing in hair follicles play a pivotal role in maintaining tissue homeostasis and hair growth cycles. Research on hair follicle aging and age-related hair loss has demonstrated that a decline in hair follicle stem cell (HFSC) activity with aging can decrease the regeneration capacity of hair follicles. This review summarizes our understanding of how age-associated HFSC intrinsic and extrinsic mechanisms can induce HFSC aging and hair loss. In addition, we discuss approaches developed to attenuate age-associated changes in HFSCs and their niches, thereby promoting hair regrowth.
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| Abstract, Accepted Manuscript(in press) [Submitted on November 11, 2022, Accepted on November 14, 2022] |
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