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Current status and prospects of organoid-based regenerative medicine
Jongman Yoo 1,* (Professor), Woo Hee Choi 1 (Research professor), Dong Hyuck Bae 1 (Research professor)
1Department of Microbiology, CHA University School of Medicine, Seongnam (13488), Republic of Korea,
2CHA Organoid Research Center, CHA University, Seongnam (13488), Republic of Korea,
3R&D Institute, ORGANOIDSCIENCES LTD, Seongnam (13488), Republic of Korea.
Abstract
Organoids derived from stem cells or organ-specific progenitors are self-organizable, self-renewable, and multicellular three-dimensional (3D) structures that can mimic the function and structure of the derived tissue. Due to such characteristics, organoids are attracting attention as an excellent ex vivo model for drug screening at the stage of drug development. In addition, since the applicability of organoids as therapeutics for tissue regeneration has been embossed, the development of various organoids-based regenerative medicine has been rapidly progressing, reaching the clinical trial stage. In this review, we give a general overview of organoids and describe current status and prospects of organoid-based regenerative medicine, focusing on organoid-based regenerative therapeutics currently under development including clinical trials.
Abstract, Accepted Manuscript(in press) [Submitted on November 24, 2022, Accepted on December 16, 2022]
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