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The role of tRNA-derived small RNAs in aging
Seung-Jae V. Lee 1,* (Professor), Seokjun G. Ha 1 (Graduate student)
1Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, South Korea
Aging is characterized by a gradual decline in biological functions, leading to the increased probability of diseases and deaths in organisms. Previous studies have identified biological factors that modulate aging and lifespan, including non-coding RNAs (ncRNAs). Here, we review the relationship between aging and tRNA-derived small RNAs (tsRNAs), ncRNAs that are generated from the cleavage of tRNAs. We describe age-dependent changes in tsRNA levels and their functions in age-related diseases, such as cancer and neurodegenerative diseases. We also discuss the association of tsRNAs with aging-regulating pathways, including mechanistic target of rapamycin (mTOR) signaling and mitochondrial respiration. We cover recent findings regarding the potential roles of tsRNAs in cellular senescence, a major cause of organismal aging. Overall, our review will provide useful information for understanding the roles of tsRNAs in aging and age-associated diseases.
Abstract, Accepted Manuscript(in press) [Submitted on November 28, 2022, Accepted on January 17, 2023]
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