BMB Reports Papers in Press available online.

Search Papers In Press
This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

 
The role of diuretic hormones (DHs) and their receptors in Drosophila.
Yangkyun Oh 1,* (Assistant Professor), Gahbien Lee1 (Undergraduate student), Heejin Jang1 (Undergraduate student)
1Department of Life Sciences, College of Natural Sciences, Ewha Womans University, Seoul 03760, Republic of Korea
Abstract
Maintaining internal homeostasis and regulating innate behavior are essential processes for the survival of animals. A highly conserved neuroendocrine system integrates sensory inputs and regulates the physiological response to environmental and internal changes in various animal species. Diuretic hormones 44 and 31 are the neuropeptides that control the body fluid secretion in Drosophila, and are homologs of mammalian corticotropin-releasing factor (CRF) and calcitonin gene-related peptide (CGRP), respectively. Diuretic hormones 44 and 31 and their receptors exhibit multiple physiological roles, including the regulation of body-fluid secretion, sleep:wake cycle, internal nutrient-sensing, and CO2-dependent response in Drosophila. The receptors of DH44 and DH31 expressed in the brain, intestine, and the Malpighian tubules direct the biological functions of the DH44 and DH31 downstream signaling pathways. In this review, we discuss the physiological and behavioral roles of the DH44 and DH31 signaling pathways, consisting of neuroendocrine cells that secrete DH44 or DH31 peptides and their receptor-expressing organs. We then describe further research that needs to be investigated to understand the regulatory mechanism of the behavioral processes mediated by those neuroendocrine systems.
Abstract, Accepted Manuscript [Submitted on February 21, 2023, Accepted on March 28, 2023]
  © KSBMB. All rights reserved. / Powered by INFOrang Co., Ltd