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ErbB3 binding protein 1 contributes to adult hippocampal neurogenesis by modulating Bmp4 and Ascl1 signaling
Youngkwan Kim 1,2 (Graduate student), Hyo Rim Ko 1,2 (Research worker), Inwoo Hwang 1,2 (Research worker), Jee-Yin Ahn 1,2,3,* (Professor)
1Department of Molecular Cell Biology and 2Single Cell Network Research Center, Sungkyunkwan University School of Medicine,
3Samsung Biomedical Research Institute, Samsung Medical Center
Neural stem cells (NSCs) in the adult hippocampus divide infrequently; the endogenous molecules modulating adult hippocampal neurogenesis (AHN) remain largely unknown. Here, we show that ErbB3 binding protein 1 (Ebp1), which plays important roles in embryonic neurodevelopment, acts as an essential modulator of adult neurogenic factors. In vivo analysis of Ebp1 neuron depletion mice showed impaired AHN with a low number of hippocampal NSCs and neuroblasts. Ebp1 leads to transcriptional repression of Bmp4 and suppression of Ascl1 promoter methylation in the dentate gyrus of the adult hippocampus reflecting an unusually high level of Bmp4 and low Ascl1 level in neurons of Ebp1-deficient mice. Therefore, our findings suggests that Ebp1 could act as an endogenous modulator of the interplay between Bmp4 and Ascl1/Notch signaling, contributing to AHN.
Abstract, Accepted Manuscript [Submitted on August 21, 2023, Accepted on September 28, 2023]
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