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This galley proof is being listed electronically before publishing the final manuscript (It's not final version).

Gut microbiota-generated metabolites: missing puzzles to hosts’ health, diseases, and aging
Yan Zhang1 (Research worker), Shibo Wei1 (Research worker), Hang Zhang1 (Research worker), Yunju Jo1 (Research worker), Jong-Sun Kang1 (Professor), Ki-Tae Ha1 (Professor), Jongkil Joo1 (Professor), Hyun Joo Lee1 (Professor), Dongryeol Ryu1,* (Professor)
1Department of Molecular Cell Biology, Single Cell Network Research Center, Sungkyunkwan University, Suwon 16419, Republic of Korea,
2Department of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea,
3Department of Hepatobiliary and Pancreatic Surgery, The Second Hospital of Jilin University, Changchun 130041, China,
4Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea,
5Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, 50612, Republic of Korea,
6Department of Obstetrics and Gynecology, Pusan National University Hospital, Busan 49241, Republic of Korea
The gut microbiota, an intricate community of bacteria residing in the gastrointestinal system, assumes a pivotal role in various physiological processes. Beyond its function in food breakdown and nutrient absorption, gut microbiota exerts a profound influence on immune and metabolic modulation by producing diverse gut microbiota-generated metabolites (GMGMs). These small molecules hold potential to impact host health via multiple pathways, which exhibit remarkable diversity, and have gained increasing attention in recent studies. Here, we elucidate the intricate implications and significant impacts of four specific metabolites, Urolithin A (UA), equol, Trimethylamine N-oxide (TMAO), and imidazole propionate, in shaping human health. Meanwhile, we also look into the advanced research on GMGMs, which demonstrate promising curative effects and hold great potential for further clinical therapies. Notably, the emergence of positive outcomes from clinical trials involving GMGMs, typified by UA, emphasizes their promising prospects in the pursuit of improved health and longevity. Collectively, the multifaceted impacts of GMGMs present intriguing avenues for future research and therapeutic interventions.
Abstract, Accepted Manuscript(in press) [Submitted on February 2, 2024, Accepted on March 20, 2024]
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