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Multifaceted Roles of Trained Immunity in Diverse Pathological Contexts
Hyo Jin Park1 (Graduate student), Su Min Kim1 (Graduate student), Un Yung Choi1 ( Research worker), Lark Kyun Kim1,* (Professor)
1Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06230, Republic of Korea,
2Department of Microbiology and 3KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju, 07478, Republic of Korea
Abstract
Trained immunity, an innate immune response characterized by enhanced cellular responsiveness, exhibits a profound memory akin to adaptive immunity. This phenomenon involves intricate metabolic and epigenetic reprogramming triggered by stimuli such as モ–glucan and BCG, shaping innate immune memory. Following elucidation of the background on trained immunity, it is important to explore its multifaceted roles in various pathological contexts. In this review, we delve into the specific contributions of trained immunity in the intricate landscape of viral infections, tumorigenesis, and diverse inflammatory diseases, shedding light on its potential as a therapeutic target, and offering comprehensive understanding of its broader immunological implications.
Abstract, Accepted Manuscript [Submitted on April 2, 2024, Accepted on May 13, 2024]
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